Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.4
USERS' SCORE
Good
Based on 10 Reviews
8.1
Supplement Facts
Serving Size: 2 Marine Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Fish Oil ConcentrateTotal Omega-3 Fatty Acids as Ethyl EstersEPA (EicosaPentaenoic Acid), min.DHA (DocosaHexaenoic Acid), min.
2000 mg1400 mg800 mg400 mg
††††
Top Medical Research Studies
9
We delved into the potential of omega-3 polyunsaturated fatty acids, specifically docosahexaenoic acid (DHA), to combat glioblastoma, one of the most aggressive brain tumors.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
Read More
8
We investigated the potential of docosahexaenoic acid (DHA) liposomes in treating glioblastoma, a challenging type of brain tumor. Using an advanced microfluidic system, we created liposomes that effectively penetrated GBM cells.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
Read More
7
We analyzed data from nine observational studies to better understand the connection between fish consumption and brain tumor risk. Our findings suggest that increasing fish intake may be linked to a 17% lower risk of developing brain cancer, with a notable dose-response relationship.
However, we also emphasize the need for further research, including well-designed cohort studies, to confirm these initial results and clarify any potential confounding factors.
However, we also emphasize the need for further research, including well-designed cohort studies, to confirm these initial results and clarify any potential confounding factors.
Read More
Most Useful Reviews
9
Improves heart function
3 people found this helpful
I've been using Omega 3 for years, and it significantly aids skin health, hair loss, and broken nails. It enhances brain and heart functions and lowers harmful cholesterol. Additionally, it's beneficial for joint osteoarthritis and has no side effects, making it suitable for all ages.
Read More
7.5
Improved memory noted
I deem the adoption of this vitamin essential for everyone, as it positively influences cardiovascular activity, slows thrombus formation, maintains immunity, and normalises blood circulation in the brain. After completing the course, I observed improved memory and more hydrated skin. Omega-3 also aids in cholesterol elimination.
Read More
7.5
Reduces bad cholesterol
It is very beneficial for the heart, blood vessels, and brain, while also reducing triglycerides and bad cholesterol, which I intend to consume regularly.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.4
- All Researches
9
We delved into the potential of omega-3 polyunsaturated fatty acids, specifically docosahexaenoic acid (DHA), to combat glioblastoma, one of the most aggressive brain tumors.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
Read More
9
We investigated the effects of eicosapentaenoic acid (EPA) alongside docosahexaenoic acid (DHA) on medulloblastoma, a common and aggressive brain tumor in children.
In our study, we treated medulloblastoma cell lines with these omega-3 fatty acids and observed notable changes. Both EPA and DHA significantly reduced the production of prostaglandin E2, a compound associated with tumor growth and inflammation. Furthermore, we saw that these treatments impaired the viability of medulloblastoma cells, meaning fewer cancer cells were able to survive and grow. Additionally, the treatment led to increased cell death and reduced the ability of these cells to form colonies.
When we moved to the in vivo part of our study, where we implanted human medulloblastoma cells into mice, the results were promising. Mice treated with DHA, with or without EPA, experienced reduced tumor growth. Notably, levels of prostaglandin E and another compound, prostacyclin, dropped significantly in the tumors of treated animals compared to those that did not receive treatment. This suggests that the omega-3 fatty acids helped create a less favorable environment for tumor growth.
Our analysis uncovered that the treatment led to a downregulation of several key genes, with CRYAB being the most significantly affected. We confirmed this finding via various techniques, including immunohistochemistry. This research hints at the potential of combining DHA and EPA in existing treatment plans to target inflammation specific to the tumor environment.
In our study, we treated medulloblastoma cell lines with these omega-3 fatty acids and observed notable changes. Both EPA and DHA significantly reduced the production of prostaglandin E2, a compound associated with tumor growth and inflammation. Furthermore, we saw that these treatments impaired the viability of medulloblastoma cells, meaning fewer cancer cells were able to survive and grow. Additionally, the treatment led to increased cell death and reduced the ability of these cells to form colonies.
When we moved to the in vivo part of our study, where we implanted human medulloblastoma cells into mice, the results were promising. Mice treated with DHA, with or without EPA, experienced reduced tumor growth. Notably, levels of prostaglandin E and another compound, prostacyclin, dropped significantly in the tumors of treated animals compared to those that did not receive treatment. This suggests that the omega-3 fatty acids helped create a less favorable environment for tumor growth.
Our analysis uncovered that the treatment led to a downregulation of several key genes, with CRYAB being the most significantly affected. We confirmed this finding via various techniques, including immunohistochemistry. This research hints at the potential of combining DHA and EPA in existing treatment plans to target inflammation specific to the tumor environment.
Read More
8
We investigated the potential of docosahexaenoic acid (DHA) liposomes in treating glioblastoma, a challenging type of brain tumor. Using an advanced microfluidic system, we created liposomes that effectively penetrated GBM cells.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
Read More
8
We explored the potential of omega-3 fatty acid, docosahexaenoic acid (DHA), to combat glioblastoma, an aggressive brain tumor. By studying patient-derived GBM neural stem-like cells, we found that DHA treatment increases its levels in these cells, assisted by a protein called FABP7. This increase in DHA was linked to a reduction in the cells' ability to migrate, suggesting a possible therapeutic approach to limit tumor spread. However, more research is needed to fully understand the implications of DHA on glioblastoma treatment.
Read More
8
Omega-3 may aid olfactory recovery
We explored how omega-3 fish oil supplementation might support smell recovery in patients after endoscopic brain tumor surgery. In a multicenter trial involving 110 patients, those receiving omega-3 alongside nasal saline experienced less persistent loss of smell compared to peers without it.
Significantly, fewer patients in the omega-3 group reported olfactory issues at three and six months post-surgery. This suggests that omega-3 could play a protective role for the olfactory system during the recovery phase. However, surgery type also influenced outcomes.
Significantly, fewer patients in the omega-3 group reported olfactory issues at three and six months post-surgery. This suggests that omega-3 could play a protective role for the olfactory system during the recovery phase. However, surgery type also influenced outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves heart function
3 people found this helpful
I've been using Omega 3 for years, and it significantly aids skin health, hair loss, and broken nails. It enhances brain and heart functions and lowers harmful cholesterol. Additionally, it's beneficial for joint osteoarthritis and has no side effects, making it suitable for all ages.
Read More
7.5
Improved memory noted
I deem the adoption of this vitamin essential for everyone, as it positively influences cardiovascular activity, slows thrombus formation, maintains immunity, and normalises blood circulation in the brain. After completing the course, I observed improved memory and more hydrated skin. Omega-3 also aids in cholesterol elimination.
Read More
7.5
Reduces bad cholesterol
It is very beneficial for the heart, blood vessels, and brain, while also reducing triglycerides and bad cholesterol, which I intend to consume regularly.
Read More
7.5
Essential for nerves
Fish oil is highly beneficial for the nerves and brain. It should be regularly consumed to maintain adequate levels in the body.
Read More
7
Enhances brain function
6 people found this helpful
Omega 3 is an essential food supplement for overall health, promoting brain function and concentration, whilst also protecting the heart and arteries. It helps lower harmful cholesterol, combats depression, and reduces inflammation. The quality of this supplement is excellent.
Read More
Frequently Asked Questions
7.5
Improved memory noted
I deem the adoption of this vitamin essential for everyone, as it positively influences cardiovascular activity, slows thrombus formation, maintains immunity, and normalises blood circulation in the brain. After completing the course, I observed improved memory and more hydrated skin. Omega-3 also aids in cholesterol elimination.
7.5
Reduces bad cholesterol
It is very beneficial for the heart, blood vessels, and brain, while also reducing triglycerides and bad cholesterol, which I intend to consume regularly.
7
Enhances brain function
6 people found this helpful
Omega 3 is an essential food supplement for overall health, promoting brain function and concentration, whilst also protecting the heart and arteries. It helps lower harmful cholesterol, combats depression, and reduces inflammation. The quality of this supplement is excellent.
7.5
Successful health improvements
4 people found this helpful
I spent a considerable time comparing various products before choosing this Omega supplement, and thankfully it was a success. At over forty and facing health issues, I was hesitant to take supplements. However, I needed it to support my heart, memory, and brain functions, manage inflammation, and reduce cholesterol levels and obesity. The taste is pleasant, and I feel fortunate to have found this product.
9
Improves heart function
3 people found this helpful
I've been using Omega 3 for years, and it significantly aids skin health, hair loss, and broken nails. It enhances brain and heart functions and lowers harmful cholesterol. Additionally, it's beneficial for joint osteoarthritis and has no side effects, making it suitable for all ages.
7.5
Preventive health effects
I ordered this Omega based on my doctor's advice for heart and brain disease prevention. I'm impressed with its quality, ingredients, and economical packaging; as a bonus, my hair has begun to shine more vibrantly.
7.5
Essential for nerves
Fish oil is highly beneficial for the nerves and brain. It should be regularly consumed to maintain adequate levels in the body.
7.5
Top health support
Doctor's Best Purified & Clear Omega 3 Fish Oil is an outstanding supplement for heart, brain, and joint health, providing 2,000 mg of omega-3s per serving. With 120 softgels offering great value, its purity and potency make it a top choice for overall health support.
8
We investigated the potential of docosahexaenoic acid (DHA) liposomes in treating glioblastoma, a challenging type of brain tumor. Using an advanced microfluidic system, we created liposomes that effectively penetrated GBM cells.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
7
We explored the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in conjunction with cisplatin on brain tumor cells. By exposing glioblastoma cells to different treatment combinations, we found that EPA boosted the antitumor effectiveness of cisplatin.
This combination increased oxidative stress and apoptosis by stimulating a specific ion channel (TRPM2) which further promoted calcium entry into the cells. However, while the treatment showed potential in enhancing cancer cell death, the overall benefits need further evaluation to determine if they significantly affect tumor progression or patient outcomes.
This combination increased oxidative stress and apoptosis by stimulating a specific ion channel (TRPM2) which further promoted calcium entry into the cells. However, while the treatment showed potential in enhancing cancer cell death, the overall benefits need further evaluation to determine if they significantly affect tumor progression or patient outcomes.
8
We sought to understand how eicosapentaenoic acid (EPA), a type of highly unsaturated fatty acid, influences brain tumors, specifically gliomas. Using various glioma models, including human samples and a rat model, we looked at how EPA could trigger tumor regression and promote cell death, known as apoptosis.
Our findings revealed that when glioma cells were exposed to EPA, significant reductions in tumor size and increased apoptosis were observed. Furthermore, we noted that EPA worked well in conjunction with gamma radiation, enhancing the effects of this common treatment.
Interestingly, our observations indicated that EPA preserved the surrounding healthy brain tissue and blood vessels, which is a significant consideration in treating brain tumors. We also found minimal inflammation in tumors treated with EPA, suggesting a more favorable safety profile compared to conventional treatments. Overall, the results indicate that EPA could be a promising addition to glioma therapies.
Our findings revealed that when glioma cells were exposed to EPA, significant reductions in tumor size and increased apoptosis were observed. Furthermore, we noted that EPA worked well in conjunction with gamma radiation, enhancing the effects of this common treatment.
Interestingly, our observations indicated that EPA preserved the surrounding healthy brain tissue and blood vessels, which is a significant consideration in treating brain tumors. We also found minimal inflammation in tumors treated with EPA, suggesting a more favorable safety profile compared to conventional treatments. Overall, the results indicate that EPA could be a promising addition to glioma therapies.
9
We delved into the potential of omega-3 polyunsaturated fatty acids, specifically docosahexaenoic acid (DHA), to combat glioblastoma, one of the most aggressive brain tumors.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
References
- Mendanha D, Casanova MR, Gimondi S, Ferreira H, Neves NM. Microfluidic-Derived Docosahexaenoic Acid Liposomes for Targeting Glioblastoma and Its Inflammatory Microenvironment. ACS Appl Mater Interfaces. 2024;16:40543. 10.1021/acsami.4c01368
- Mendanha D, Gimondi S, Costa BM, Ferreira H, Neves NM. Microfluidic-derived docosahexaenoic acid liposomes for glioblastoma therapy. Nanomedicine. 2023;53:102704. 10.1016/j.nano.2023.102704
- Öcal Ö, Nazıroğlu M. Eicosapentaenoic acid enhanced apoptotic and oxidant effects of cisplatin via activation of TRPM2 channel in brain tumor cells. Chem Biol Interact. 2022;359:109914. 10.1016/j.cbi.2022.109914
- Choi WS, Xu X, Goruk S, Wang Y, Patel S, et al. FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells. Nutrients. 2021;13. 10.3390/nu13082664
- Yan CH, Rathor A, Krook K, Ma Y, Rotella MR, et al. Effect of Omega-3 Supplementation in Patients With Smell Dysfunction Following Endoscopic Sellar and Parasellar Tumor Resection: A Multicenter Prospective Randomized Controlled Trial. Neurosurgery. 2020;87:E91. 10.1093/neuros/nyz559
- Kim S, Jing K, Shin S, Jeong S, Han SH, et al. ω3-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: In vitro and in vivo. Oncol Rep. 2018;39:239. 10.3892/or.2017.6101
- Shinde RL, Devarajan PV. Docosahexaenoic acid-mediated, targeted and sustained brain delivery of curcumin microemulsion. Drug Deliv. 2017;24:152. 10.1080/10717544.2016.1233593
- Lian W, Wang R, Xing B, Yao Y. Fish intake and the risk of brain tumor: a meta-analysis with systematic review. Nutr J. 2017;16:1. 10.1186/s12937-016-0223-4
- Harvey KA, Xu Z, Saaddatzadeh MR, Wang H, Pollok K, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015;122:547. 10.3171/2014.10.JNS14759
- Wang F, Bhat K, Doucette M, Zhou S, Gu Y, et al. Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. Curr Mol Med. 2011;11:503.
- Cui PH, Petrovic N, Murray M. The ω-3 epoxide of eicosapentaenoic acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin D1/CDK4 down-regulation. Br J Pharmacol. 2011;162:1143. 10.1111/j.1476-5381.2010.01113.x
- Nasrollahzadeh J, Siassi F, Doosti M, Eshraghian MR, Shokri F, et al. The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. Lipids Health Dis. 2008;7:45. 10.1186/1476-511X-7-45
- Denkins Y, Kempf D, Ferniz M, Nileshwar S, Marchetti D. Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. J Lipid Res. 2005;46:1278.
- Gramaglia A, Loi GF, Mongioj V, Baronzio GF. Increased survival in brain metastatic patients treated with stereotactic radiotherapy, omega three fatty acids and bioflavonoids. Anticancer Res. 1999;19:5583.
- Ljungblad L, Bergqvist F, Tümmler C, Madawala S, Olsen TK, et al. Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E and suppress tumor growth in medulloblastoma. Life Sci. 2022;295:120394. 10.1016/j.lfs.2022.120394
- Yuan Y, Shah N, Almohaisin MI, Saha S, Lu F. Assessing fatty acid-induced lipotoxicity and its therapeutic potential in glioblastoma using stimulated Raman microscopy. Sci Rep. 2021;11:7422. 10.1038/s41598-021-86789-9
- Salvati S, Natali F, Attorri L, Raggi C, Di Biase A, et al. Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells. Neurochem Int. 2004;44:331.
- Leaver HA, Bell HS, Rizzo MT, Ironside JW, Gregor A, et al. Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma. Prostaglandins Leukot Essent Fatty Acids. 2002;66:19.
